Teachers:
Professor Odd O. Aalen, Department of Biostatistics, IMB (Responsible for the course)
Associate professor Bettina Kulle Andreassen, Epi-gen, Ahus, UiO
Postdoc Jon Michael Gran, Department of Biostatistics, IMB
Associate professor Tron Anders Moger, Department of Biostatistics, IMB
Research Fellow Morten Valberg, Department of Biostatistics, IMB
Monday 2. September:
08.30-09.00: Registration. (Outside Lille Auditorium in Domus Medica)
09.00-11.15: Data and descriptive statistics. (Aalen).
Literature: Aalen chap. 1 og 2, Kirkwood and Sterne chap. 3 and 4
11.30-12.45: Exercises: Introduction to SPSS. - GA21 R-211 PC-stue DM tilbygg/ GA02 A1.1022 Datarom, DO
Exercises: 1 and 2 in the exercise booklet (Aalen, Gran)
12.45-13.45: Lunch break
13.45-15.45: Basic concepts of probability. (Aalen).
Literature: Aalen chap. 3.1-3.7. Kirkwood and Sterne chap. 14
Tuesday 3. September:
08.30-09.15: Bayes law. Sensitivity, specificity. (Aalen).
Literature: Aalen chap. 3.9 and 3.10, Kirkwood and Sterne chap. 36.2
09.30-11.00: Binomial distribution. (Aalen).
Literature: Aalen chap. 4, Kirkwood and Sterne section 15.1 and 15.2
11.15-12.15: Exercises: 9 and 12 in the exercise booklet. (Aalen)
12.15-13.15: Lunch break
13.15-14.00: The normal distribution. (Andreassen).
Literature: Aalen chap. 5, Kirkwood and Sterne chap. 5
14.15-15.00: Exercises. Exercise 14 in the exercise booklet.
(Andreassen)
15.15-15.45: Discussion of exercises. (Andreassen)
Wednesday 4. September:
08.30-10.45: Introduction to hypothesis testing and confidence intervals. One-sample Student’s test and conf. interval. (Andreassen).
Literature: Aalen chap. 8.1-8.5, Kirkwood and Sterne chap. 4, 6 and 7
11.00-12.00: Exercises. Exercise 13 in the exercise booklet. (Andreassen, Aalen) - GA21 R-211 PC-stue DM tilbygg/ GA01 2170B PC-stue 2. et, DM
12.00-12.45: Lunch break
12.45-14.15: Two sample Student’s test and confidence interval. (Andreassen).
Literature: Aalen chap. 8.6 og 8.7, Kirkwood and Sterne chap. 7
14.15-15.45: Exercises. Exercise 15 in the exercise booklet. (Andreassen, Aalen). - GA21 R-211 PC-stue DM tilbygg/ GA01 2170B PC-stue 2. et, DM
Thursday 5. September:
08.30-11.15: Transformations. Non-parametric methods. (Aalen).
Literature: Aalen chap. 8.8, Kirkwood and Sterne chap. 13 and 30.2
11.15-12.15: Exercises. Altman 9.2 and 9.4 and exercise 4 (all in the booklet). (Gran, Aalen)- GA21 R-211 PC-stue DM tilbygg/ GA02 A1.1022 Datarom, DO
12.15-13.00: Lunch break
13.00-14.30: Regression analysis, correlation. (Aalen).
Literature: Aalen chap. 11.1-11.3, Kirkwood and Sterne chap. 10
14.45-15.45: Exercises. (Gran, Aalen)
3 and 7 in the exercise booklet - GA21 R-211 PC-stue DM tilbygg/ GA02 A1.1022 Datarom, DO
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Exercises for the intervening period:
You should read through the material from the first period and do the following exercises:
8, 10 and 11 in the exercise booklet
We shall go through the exercises at the beginning of the next period.
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Monday 16. September:
08.30-09.30: Discussion of the exercises from the intervening period. (Aalen)
09.45-11.15: Regression analysis cont., multiple regression. (Aalen).
Literature: Aalen chap. 11.4-11.6, Kirkwood and Sterne chap. 11 and 12
11.30-12.30: Exercises. (Gran, Aalen) - GA21 R-211 PC-stue DM tilbygg/ GA01 2170B PC-stue 2. et, DM
Exercises: Altman 11.2 + 18 in exercise booklet.
12.30-13.15: Lunch break
13.15-15.00: Some more about regression. Confounding. Interaction. (Aalen)
Literature: Kirkwood and Sterne chap. 38
Tuesday 17. September:
08.30-09.30: Epidemiologic design and basic concepts. (Aalen)
09.45-11.30: Principles for organizing clinical trials. (Aalen).
Literature: Aalen chap. 9 og 10, Kirkwood and Sterne chap. 32 and 34
11.30-12.15: Lunch break
12.15-14.00: Statistical analysis of proportions. Odds ratio, relative risk etc. (Valberg).
Literature: Aalen chap. 6.1-6.4, Kirkwood and Sterne chap. 15 and 16
14.15-15.15: Exercises. (Valberg).
Exercises 16 and 17 in the booklet
15.15-15.45: Discussion of exercises.
Wednesday 18. September:
08.30-10.15: Analyzing tables (chi squared, exact and Monte Carlo tests) (Valberg)
Literature: Aalen chap. 6.5, Kirkwood and Sterne chap. 17
10.30-11.30: Exercises. (Valberg, Aalen) - GA21 R-211 PC-stue DM tilbygg/ GA01 2170B PC-stue 2. et, DM
Exercises: Altman 10.1a, 10.3, 10.7 (see Exercise booklet).
11.30-12.15: Lunch break
12.15-14.30: Logistic regression (Moger)
Literature: Aalen Chap. 12, Kirkwood and Sterne, Chap. 19, 20.
14.45-15.45: Exercise 23 in the booklet (Moger, Aalen) - GA21 R-211 PC-stue DM tilbygg/ GA01 2170B PC-stue 2. et, DM
Thursday 19. September:
08.30-09.45: Sample size and power. (Gran).
Literature: Aalen chap. 9.6, Kirkwood and Sterne kap. 35
10.00-11.00: Exercises. (Gran)
Exercise 19 from booklet
11.15-12.15: Survival analysis. (Gran).
Literature: Aalen chap. 13, Kirkwood and Sterne chap. 26
12.15-13.00: Lunch break
13.00-13.45: Survival analysis cont. (Gran).
14.00-15.15: Exercises with discussion. (Gran, Aalen) - GA21 R-211 PC-stue DM tilbygg/ GA01 2170B PC-stue 2. et, DM
Exercises 5 and 6 from booklet
15.30-15.45: Summary. (Gran)
Course exam:
A take home exam will be handed out at the end of the course. This should be solved at home and then returned within a specified deadline.