KJM9280 ¨C NMR Spectroscopy

Course content

You are learning practical aspects of optimization of NMR experiments while actually using real NMR spectrometers. You are learning the basics of selecting acquisition- and processing-parameters. You learn how to acquire data manually and in automatic mode. Furthermore, you are taught how to process two dimensional NMR spectra. The course gives an introduction to parameter differences in one- and two dimensional NMR experiments, a first theoretical look into T1 and T2 relaxation (very superficially), and also an introduction to how computers, programs, and storage places for NMR data are connected and used at UiO NMR Center

Learning outcome

After completion of the course:

• you are able to prepare and execute NMR experiments with the nuclei 1H, 13C, 19F, and 31P, and similarly for the experiments APT and DEPT
• you can use the automation program ICONNMR as a helping tool for running a series of 2-dimensional NMR-experiments (COSY, TOCSY, NOESY, ROESY, HSQC, HMBC, S-HSQC, and S-HMBC) and also be able to perform simple solvent suppression experiments
• you can process and understand the information content in two-dimensional NMR experiments
• you are trained in setting up and running basic NMR experiments
• you can apply the results coming out of NMR experiments in order to elucidate the exact atom by atom identity of new and unknown molecules

Admission to the course

PhD candidates from the University of Oslo should apply for classes and register for examinations through?Studentweb.

If a course has limited intake capacity, priority will be given to PhD candidates who follow an individual education plan where this particular course is included. Some national researchers¡¯ schools may have specific rules for ranking applicants for courses with limited intake capacity.

PhD candidates who have been admitted to another higher education institution must?apply for a position as a visiting student?within a given deadline.

Recommended previous knowledge

KJM3000 ¨C Applied Spectroscopy and KJM3200 ¨C Organic Chemistry II

Overlapping courses

• 5 credits overlap with KJM5280 ¨C NMR Spectroscopy.

Teaching

The course extends over the whole semester. The teaching consists of the following:

• approximately?25 hours of practical training in NMR spectroscopy at NMR-spectrometers is be completed during a 10 day period.
• 5 hours of lectures/theory on day 1 in the course. Mid way in the semester a two hour seminar is held where the topic is various ways of writing the report/project assay.
• A 1 hour practical test on an NMR spectrometer, approximately two weeks into the course, must be passed before you hand in the report and present your lecture.
• Two weeks after the last student has passed the 1-hour practical test on the NMR? spectrometers, a two hour voluntary colloquium is offered every week for four weeks where report writing and spectrum interpretation are covered

As?the?teaching involves laboratory and/or field work, you should consider taking out a separate travel and personal risk insurance.?Read about your insurance cover as a student.?

Examination

The course does not have a classical exam. Three following evaluations has to be passed for getting the course approved:?

• One hour practical test at a NMR spectrometer
• Delivering of written report/project description
• An oral power point presentation where the thinking and arguing in the written report/project description is presented.

The practical test needs to be passed before you can hand in the written report and the oral presentation.

It will also be counted as one of the three attempts to get this course approved if you go through the same approval procedure for one of the following courses: KJM5280 ¨C NMR Spectroscopy

Examination support material

All examination support materials is allowed.

Language of examination

You may submit your response in Norwegian, Swedish, Danish or English.

Grading scale

Grades are awarded on a pass/fail scale. Read more about?the grading system.

Resit an examination

If you fail to pass the three assessments and thus fail the course, the entire course must be taken again next Autumn. If you are sick during an assessment, you can take the assessment a few days later.

More about examinations at UiO

• Use of sources and citations
• Special exam arrangements due to individual needs
• Withdrawal from an exam
• Illness at exams / postponed exams
• Explanation of grades and appeals
• Resitting an exam
• Cheating/attempted cheating

You will find further guides and resources at the web page on examinations at UiO.