KJM9280 ¨C NMR Spectroscopy

Course content

You are learning practical aspects of optimization of NMR experiments while actually using real NMR spectrometers. You are learning the basics of selecting acquisition- and processing-parameters. You learn how to acquire data manually and in automatic mode. Furthermore, you are taught how to process two-dimensional NMR?spectra. The course gives also an introduction to how computers,?programs, and storage places for NMR data are connected and used at UiO NMR Center.?The knowledge is applied in a written report in which students must identify an unknown molecule using NMR spectra that they have recorded themselves.

Learning outcome

After completion of the course, you:

• can calibrate an NMR spectrometer (lock, tune/match, shim) to a new sample
• are able to prepare and execute manual NMR experiments with the nuclei 1H, 13C, 19F, and 31P across old and new spectrometers.
• can use the semi automation program IconNMR as a helping tool for running a series of 2-dimensional NMR-experiments (COSY, TOCSY, NOESY, ROESY, HSQC, HMBC, SHSQC, SHMBC and simultaneous 1H-19F experiments) and are also able to perform simple solvent suppression experiments
• can process and understand the information content in two-dimensional NMR experiments
• can apply the results coming out of NMR experiments in research where the goal is to identify an unknown molecule

Admission to the course

PhD candidates from the University of Oslo should apply for classes and register for examinations through?Studentweb.

If a course has limited intake capacity, priority will be given to PhD candidates who follow an individual education plan where this particular course is included. Some national researchers¡¯ schools may have specific rules for ranking applicants for courses with limited intake capacity.

PhD candidates who have been admitted to another higher education institution must?apply for a position as a visiting student?within a given deadline.

Recommended previous knowledge

KJM3000 ¨C Applied Spectroscopy and KJM3200 ¨C Organic Chemistry II

Overlapping courses

• 5 credits overlap with KJM5280 ¨C NMR Spectroscopy.

Teaching

The course extends over the whole semester. The teaching consists of the following:

• Practical and intensive training in NMR spectroscopy on NMR spectrometers in approximately 4 full days. The training can take place in pairs or individually as desired. The student then records additional data on his/her own without guidance.
• 3 lectures of 2 hours each on basic NMR theory, instrument calibration, overview of 2D techniques, parameter settings, and report writing. The last lecture also provides an insight into more advanced NMR experiments.
• Practical exam on an NMR spectrometer of 1 hour, typically 1-3 weeks after completing practical training. The exam must be passed before submitting a written report and conducting an oral presentation.

As?the?teaching involves laboratory and/or field work, you should consider taking out a separate travel and personal risk insurance.?Read about your insurance cover as a student.?

Examination

The course does not have a classical exam. Three following evaluations has to be passed for getting the course approved:?

• One hour practical test at a NMR spectrometer.
• Submission of a written report on the identification of an unknown molecule
• Oral presentation where the argumentation in the report is described

The practical test needs to be passed before you can hand in the written report and the oral presentation.

It will also be counted as one of the three attempts to get this course approved if you go through the same approval procedure for one of the following courses: KJM5280 ¨C NMR Spectroscopy

Examination support material

All examination support materials is allowed.

Language of examination

You may submit your response in Norwegian, Swedish, Danish or English.

Grading scale

Grades are awarded on a pass/fail scale. Read more about?the grading system.

Resit an examination

If you fail to pass the three assessments and thus fail the course, the entire course must be taken again next Autumn. If you are sick during an assessment, you can take the assessment a few days later.

More about examinations at UiO

• Use of sources and citations
• How to use AI as a student
• Special exam arrangements due to individual needs
• Withdrawal from an exam
• Illness at exams / postponed exams
• Explanation of grades and appeals
• Resitting an exam
• Cheating/attempted cheating

You will find further guides and resources at the web page on examinations at UiO.