This dissertation explores how sound and music can be used to create physical vibrations that affect cell cultures. In particular, it looks into how cells sense and respond to physical changes (e.g., sound vibrations) and the possible role of rhythmic stimulation in their sensing process.
Furthermore, this study seeks to bridge the gap between various academic disciplines by drawing upon theories and methodologies from fields like biology, music technology, and physics. Ultimately, one of the main goals is to offer a fresh perspective for further exploration.
This interdisciplinary approach led to lab experiments on rhythmic sound vibrations in human cell cultures using music technology techniques. In the experiment, various experimental conditions were investigated, for example, continuous vibrations and rhythmic (pulse-like) vibrations. The stimuli were generated using digital signal processing and a custom-built setup. The biological cells were analysed using microscopic image analysis and computer vision.
The findings of this work indicate variations in cell structures (F-actin filaments) and growth cycles depending on different vibration conditions. This suggests a strong link between cell characteristics and mechanical factors like acceleration and shear stress.
The biological mechanisms responsible for these effects still need to be characterised, inspiring further research on the impact of rhythmic stimulation on cells.
The project has been carried out within the project Artificial Biomimetic systems – the Niche of Islet Organoids (ABINO) funded by UiO:Life Science.
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Trial lecture
Designated topic: "Concepts of rhythm in physics and music"
Evaluation committee
- Associate professor Catherine Quilliet, Université Grenoble Alpes (first opponent)
- Professor Eduardo Miranda, University of Plymouth (second opponent)
- Professor emeritus Rolf Inge God?y, University of Oslo (committee administrator)
Chair of the defence
- Head of Department of Musicology Zafer ?zgen, University of Oslo
Supervisors
- Professor Alexander Refsum Jensenius, University of Oslo
- Professor Anne Danielsen, University of Oslo
- Doctor Hanne Scholtz, University of Oslo
- Doctor Petter Angell Olsen, University of Oslo