Jens Petter Berg

• Waage, Christin; Jenum, Anne Karen; Mdala, Ibrahimu; Lee-?deg?rd, Sindre; Br?nd, Anja Maria & Sletner, Line [Vis alle 8 forfattere av denne artikkelen] (2025). Diabetes and prediabetes among women universally screened for gestational diabetes: a multi-ethnic, population-based, prospective study with eleven years follow-up. BMC Public Health. 25(1). doi: 10.1186/s12889-025-22493-x. Fulltekst i vitenarkiv Vis sammendrag

  Background Gestational diabetes (GDM) is a strong risk factor for later development of diabetes. However, data are scarce on the long-term risk for diabetes or prediabetes diagnosed by HbA1c, in non-selected, multi-ethnic populations universally screened for GDM using the WHO2013 criteria. We aimed to investigate the development of diabetes or prediabetes eleven years after the index pregnancy and identify risk factors in pregnancy or shortly after. Methods A population-based cohort study of 360 women with complete eleven years follow-up data for diabetes (HbA1c¡Ý48 mmol/mol) or prediabetesADA (HbA1c 39¨C47 mmol/mol). Women were enrolled in gestational week 15 and universally screened with an oral glucose tolerance test in week 28. We performed least absolute shrinkage and selection operator (LASSO) regression to identify predictors of future diabetes or prediabetesADA and constructed a nomogram to predict individual risks. Results Diabetes or prediabetesADA combined, was found in 26.9%, and the prevalence was slightly higher in previous GDM compared with non-GDM women (35.6% versus 23.5%; p=0.019). The relative risk (RR) for developing diabetes or prediabetesADA was moderately elevated in GDM compared with non-GDM women (1.4 [1.0, 1.9], p=0.035). Seven women (1.9%) had diabetes and all of these except for one, had previous GDM. Hence, the crude prevalence was 5.8% among GDM women vs. 0.4% among non-GDM women. The RR for developing diabetes was substantially higher in GDM vs. non-GDM women (14.8 [2.6, 277.1], p=0.012). PrediabetesADA was found in 25% and the RR for prediabetesADA was not significantly increased for GDM compared to non-GDM women (1.3 [0.9, 1.8], p=0.143). Among Europeans, 17.0% had diabetes or prediabetesADA, compared to 43.0% among South Asians (p<0.001) and 34.4% among other ethnicities (p=0.002). The most significant predictors identified from the LASSO were HbA1c measured in early pregnancy, ethnicity, and a family history of diabetes. Conclusions The risk for developing diabetes was low, overall and among GDM women. Still GDM represented a strong risk for diabetes, but not for prediabetesADA. HbA1c early in pregnancy, non-European ethnicity, and a family history of diabetes were the strongest risk factors for developing diabetes or prediabetesADA.

• Meer, Dennis van der; Rahman, Mohammad Zillur; Ottas, Aigar; Parekh, Pravesh; Kutrolli, Gleda & Stinson, Sara Elizabeth [Vis alle 37 forfattere av denne artikkelen] (2025). Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers. Nature Communications. 16(1). doi: 10.1038/s41467-025-60058-z.
• Ree, Anne Hansen; Benth, Jurate Saltyte; Hamre, Hanne Mari; Kersten, Christian; Hofsli, Eva & Guren, Marianne [Vis alle 14 forfattere av denne artikkelen] (2024). First-line oxaliplatin-based chemotherapy and nivolumab for metastatic microsatellite-stable colorectal cancer¡ªthe randomised METIMMOX trial. British Journal of Cancer. ISSN 0007-0920. 130(12), s. 1921¨C1928. doi: 10.1038/s41416-024-02696-6. Fulltekst i vitenarkiv Vis sammendrag

  Background We evaluated first-line treatment of metastatic microsatellite-stable colorectal cancer with short-course oxaliplatin-based chemotherapy alternating with immune checkpoint blockade. Methods Patients were randomly assigned to chemotherapy (the FLOX regimen; control group) or alternating two cycles each of FLOX and nivolumab (experimental group). Radiographic response assessment was done every eight weeks with progression-free survival (PFS) as the primary endpoint. Cox proportional-hazards regression models estimated associations between PFS and relevant variables. A post hoc analysis explored C-reactive protein as signal of responsiveness to immune checkpoint blockade. Results Eighty patients were randomised and 38 in each group received treatment. PFS was comparable¡ªcontrol group: median 9.2 months (95% confidence interval (CI), 6.3¨C12.7); experimental group: median 9.2 months (95% CI, 4.5¨C15.0). The adjusted Cox model revealed that experimental-group subjects aged ¡Ý60 had significantly lowered progression risk (p?=?0.021) with hazard ratio 0.17 (95% CI, 0.04¨C0.76). Experimental-group patients with C-reactive protein <5.0?mg/L when starting nivolumab (n?=?17) reached median PFS 15.8 months (95% CI, 7.8¨C23.7). One-sixth of experimental-group cases (all KRAS/BRAF-mutant) achieved complete response. Conclusions The investigational regimen did not improve the primary outcome for the intention-to-treat population but might benefit small subgroups of patients with previously untreated, metastatic microsatellite-stable colorectal cancer. Trial registration ClinicalTrials.gov number, NCT03388190 (02/01/2018).

• Denver, Paul; Tortorelli, Lucas; Hov, Karen Roksund; Berg, Jens Petter; Giil, Lasse Melv?r & Nazmi, Arshed [Vis alle 12 forfattere av denne artikkelen] (2024). Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium. Brain, Behavior, and Immunity - Health (BBI - Health). 43, s. 1¨C13. doi: 10.1016/j.bbih.2024.100920. Fulltekst i vitenarkiv Vis sammendrag

  Delirium is a highly prevalent neuropsychiatric syndrome characterised by acute and fluctuating impairments in attention and cognition. Mechanisms driving delirium are poorly understood but it has been suggested that blood cytokines and chemokines cross the blood brain barrier during delirium, directly impairing brain function. It is not known whether these molecules reach higher brain levels when the blood cerebrospinal fluid barrier (BCSFB) is impaired. Here, in human hip-fracture patients, we tested the influence of BCSFB integrity on CSF levels of chemokines and assessed their association with delirium. CSF levels of IP-10, eotaxin, eotaxin 3 and TARC showed weak to moderate correlations with BCSFB permeability, as measured by the Qalbumin ratio, while MCP1, IL-8, MIP1¦Á and MIP1¦Â showed no significant correlation. Chemokines were not associated with delirium in univariate analysis or when stratified on dementia status, but exploratory analyses showed that elevated Eotaxin (CCL11) and MIP1¦Á (CCL3) were associated with prevalent delirium. Modelling acute systemic inflammation, we used bacterial LPS (250 ¦Ìg/kg) or sterile laparotomy surgery in mice to demonstrate de novo synthesis of chemokines at the choroid plexus (CP) and microvasculature. Gene expression data showed CP-enriched expression of Il1b, Tnfa, Cxcl1 and Ccl3 in both models and immunohistochemistry showed cytokine and chemokine synthesis in CP stromal (IL-1¦Â, CCL2/MCP1) or epithelial cells (CXCL10/IP-10) cells and at the microvasculature. Larger studies are required to confirm these human findings on chemokine associations with BCSFB permeability and prevalent delirium. Preclinical studies are warranted to determine whether chemokines might play a role in the pathophysiology of delirium.

• ?ystese, Kristin Astrid Berland; Olarescu, Nicoleta Cristina; Lindskog, Cecilia; Xheka, Fabjola; Berg-Johnsen, Jon & Berg, Jens Petter [Vis alle 8 forfattere av denne artikkelen] (2024). Stem cell-associated transcription factors in non-functioning pituitary neuroendocrine tumours. Free Neuropathology. 5. doi: 10.17879/freeneuropathology-2024-5396. Fulltekst i vitenarkiv
• N?ss-Andresen, Marthe-Lise; Jenum, Anne Karen; Berg, Jens Petter; Falk, Ragnhild S?rum & Sletner, Line (2023). The impact of recommending iron supplements to women with depleted iron stores in early pregnancy on use of supplements, and factors associated with changes in iron status from early pregnancy to postpartum in a multi-ethnic population-based cohort. BMC Pregnancy and Childbirth. 23:350(1), s. 1¨C13. doi: 10.1186/s12884-023-05668-5.
• N?ss-Andresen, Marthe-Lise; Jenum, Anne Karen; Berg, Jens Petter; Falk, Ragnhild S?rum & Sletner, Line (2022). Prevalence of postpartum anaemia and iron deficiency by serum ferritin, soluble transferrin receptor and total body iron, and associations with ethnicity and clinical factors: a Norwegian population-based cohort study. Journal of Nutritional Science (JNS). 11. doi: 10.1017/jns.2022.45. Fulltekst i vitenarkiv
• ?ystese, Kristin Astrid Berland; Casar-Borota, Olivera; Berg-Johnsen, Jon; Berg, Jens Petter & Bollerslev, Jens (2022). Distribution of E- and N-cadherin in subgroups of non-functioning pituitary neuroendocrine tumours. Endocrine. ISSN 1355-008X. 77(1), s. 151¨C159. doi: 10.1007/s12020-022-03051-6. Fulltekst i vitenarkiv
• Jansen, Aina; Aaseth, Jan Olav; Lyche, Jan Ludvig; Berg, Jens Petter; M¨¹ller, Mette Helen Bj?rge & Lydersen, Stian [Vis alle 7 forfattere av denne artikkelen] (2022). Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption? Chemosphere. ISSN 0045-6535. 313, s. 1¨C8. doi: 10.1016/j.chemosphere.2022.137461. Fulltekst i vitenarkiv Vis sammendrag

  Background Bariatric surgery results in weight loss, marked endocrine changes and the release of persistent organic pollutants (POPs). The release of POPs might cause endocrine disruption. The study aimed to explore associations between POPs and adiponectin, leptin and ghrelin in subjects undergoing bariatric surgery. Methods: The study included 63 subjects with severe obesity (men/women: 13/50), age (years): 45.0 (8.5), and BMI (kg/m2) 39.1 (3.4). Analyses of adiponectin, leptin and ghrelin and POPs (hexachlorobenzene (HCB), dichlorodiphenyldichloroethylene (p,p¡¯-DDE), polychlorinated biphenyl (PCB) 118 (dioxin-like compound; dl), and sum 6 PCB (PCB 28, -52, ?101, ?138, ?153, and ?180) were performed before and 12 months after bariatric surgery. Results: There were significant increases in adiponectin and all POPs and a fall in leptin after surgery. The main finding was the highly significant associations between adiponectin and all POPs. The increase in HCB explained 38% of the variation in adiponectin. Conclusions: If the POP-associated increase in adiponectin is a causal effect, the release of POPs might have important clinical consequences. Adiponectin has both positive and negative clinical effects exerted by essentially unknown mechanisms. The effects of released POPs on the metabolic functions in subjects undergoing bariatric surgery deserve further evaluation. ? 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

• Sundet, Birgitte Kordt; Kreyberg, Ina; Staff, Anne Cathrine; Carlsen, Karin Cecilie L?drup; Bains, Karen Eline Stensby & Berg, Jens Petter [Vis alle 20 forfattere av denne artikkelen] (2022). The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers. Biology of Sex Differences. 13(1). doi: 10.1186/s13293-022-00443-1. Fulltekst i vitenarkiv Vis sammendrag

  In utero exposure to nicotine, largely assessed by smoking, is a risk factor for impaired offspring health, while potential effects of non-combustible nicotine use such as snus (oral moist tobacco), are less well-known. Maternal serum concentrations of placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) may be viewed as ¡°placenta health markers¡±, known to differ by fetal sex. Maternal smoking during pregnancy has been associated with lower levels of circulating sFlt-1, while the effect of snus on placenta-associated angiogenic factors is unknown. Our aim was to explore if snus and/or smoking exposure was associated with midpregnancy maternal levels of sFlt-1, PlGF and sFlt-1/PlGF ratio if these associations were modified by fetal sex. Methods Midpregnancy (16¨C22 gestational weeks) serum from 2603 Scandinavian women enrolled in the population-based multi-center PreventADALL (Preventing Atopic Dermatitis and ALLergies in children) study was analysed for sFlt-1 and PlGF concentrations by electrochemiluminescence, deriving the sFlt-1/PGF ratio. Nicotine use was assessed by electronic questionnaires at enrollment in 2278 of the women. Univariable and multivariable linear regression models on log transformed outcomes were used to assess the association between nicotine use and biomarker levels. Interaction terms were included to identify whether the associations were modified by fetal sex. Results Median sFlt-1, PlGF and sFlt-1/PlGF ratios among women with nicotine exposure information were similar to those of all included women and differed by fetal sex. Current snus use was significantly associated with reduced maternal circulating PlGF levels in adjusted analyses [¦Â???0.12, (95% CI???0.20; 0.00) compared to never use, p?=?0.020]. A significant interaction between fetal sex and snus exposure was observed for PIGF (p?=?0.031). Prior or periconceptional snus use was significantly associated with PIGF in male fetus pregnancies [¦Â???0.05 (95% CI???0.09 to (??0.02)) and ¦Â???0.07 (95% CI???0.12 to (??0.02)) compared to never use, p?=?0.002]. Smoking was not significantly associated with any circulating biomarkers levels. Conclusions Midpregnancy maternal angiogenic profile differed by periconceptional snus use and fetal sex. Snus exposure, perceived as ¡°safe¡± by users, before or during pregnancy seems to affect midpregnancy placental health in a sex dimorphic manner.

• Wendel, Kristina; Pfeiffer, Helle Cecilie; Fugelseth, Drude; Nestaas, Eirik; Domell?f, Magnus & Sk?lhegg, Bj?rn Steen [Vis alle 42 forfattere av denne artikkelen] (2021). Effects of nutrition therapy on growth, inflammation and metabolism in immature infants: a study protocol of a double-blind randomized controlled trial (ImNuT). BMC Pediatrics. 21. doi: 10.1186/s12887-020-02425-x. Fulltekst i vitenarkiv Vis sammendrag

  Background: Current nutritional management of infants born very preterm results in significant deficiency of the essential fatty acids (FAs) arachidonic acid (ARA) and docosahexaenoic acid (DHA). The impact of this deficit on brain maturation and inflammation mediated neonatal morbidities are unknown. The aim of this study is to determine whether early supply of ARA and DHA improves brain maturation and neonatal outcomes in infants born before 29 weeks of gestation. Methods: Infants born at Oslo University Hospital are eligible to participate in this double-blind randomized controlled trial. Study participants are randomized to receive an enteral FA supplement of either 0.4 ml/kg MCT-oil? (medium chain triglycerides) or 0.4 ml/kg Formulaid? (100 mg/kg of ARA and 50 mg/kg of DHA). The FA supplement is given from the second day of life to 36 weeks' postmenstrual age (PMA). The primary outcome is brain maturation assessed by Magnetic Resonance Imaging (MRI) at term equivalent age. Secondary outcomes include quality of growth, incidence of neonatal morbidities, cardiovascular health and neuro-development. Target sample size is 120 infants (60 per group), this will provide 80% power to detect a 0.04 difference in mean diffusivity (MD, mm2/sec) in major white matter tracts on MRI. Discussion: Supplementation of ARA and DHA has the potential to improve brain maturation and reduce inflammation related diseases. This study is expected to provide valuable information for future nutritional guidelines for preterm infants. Trial registration: Clinicaltrials.gov ID: NCT03555019 . Registered 4 October 2018- Retrospectively registered.

• Rognes, Ingrid Nygren; Pischke, S?ren Erik; Ottestad, William; R?islien, Jo; Berg, Jens Petter & Johnson, Christina [Vis alle 8 forfattere av denne artikkelen] (2021). Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study. Molecular medicine (Cambridge, Mass. Print). ISSN 1076-1551. 27(1), s. 1¨C13. doi: 10.1186/s10020-021-00286-3. Fulltekst i vitenarkiv Vis sammendrag

  Background - Complement activation is a central mechanism in systemic inflammation and remote organ dysfunction following major trauma. Data on temporal changes of complement activation early after injury is largely missing. We aimed to describe in detail the kinetics of complement activation in individual trauma patients from admission to 10?days after injury, and the association with trauma characteristics and outcome. Methods - In a prospective cohort of 136 trauma patients, plasma samples obtained with high time resolution (admission, 2, 4, 6, 8?h, and thereafter daily) were assessed for terminal complement complex (TCC). We studied individual TCC concentration curves and calculated a summary measure to obtain the accumulated TCC response 3 to 6?h after injury (TCC-AUC3¨C6). Correlation analyses and multivariable linear regression analyses were used to explore associations between individual patients¡¯ admission TCC, TCC-AUC3¨C6, daily TCC during the intensive care unit stay, trauma characteristics, and predefined outcome measures. Results - TCC concentration curves showed great variability in temporal shapes between individuals. However, the highest values were generally seen within the first 6?h after injury, before they subsided and remained elevated throughout the intensive care unit stay. Both admission TCC and TCC-AUC3¨C6 correlated positively with New Injury Severity Score (Spearman¡¯s rho, p-value 0.31, 0.0003 and 0.21, 0.02) and negatively with admission Base Excess (??0.21, 0.02 and ??0.30, 0.001). Multivariable analyses confirmed that deranged physiology was an important predictor of complement activation. For patients without major head injury, admission TCC and TCC-AUC3¨C6 were negatively associated with ventilator-free days. TCC-AUC3¨C6 outperformed admission TCC as a predictor of Sequential Organ Failure Assessment score at day 0 and 4. Conclusions - Complement activation 3 to 6?h after injury was a better predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome than admission TCC. Our data suggest that the greatest surge of complement activation is found within the first 6?h after injury, and we argue that this time period should be in focus in the design of future experimental studies and clinical trials using complement inhibitors.

• Johannessen, Karl Arne; Wear, Nina Kristin Steen; Toska, Karin; Hansb?, Morten; Berg, Jens Petter & Fosse, Erik (2021). Pathologic Blood Samples Tolerate Exposure to Vibration and High Turbulence in Simulated Drone Flights, but Plasma Samples Should be Centrifuged after Flight. IEEE Journal of Translational Engineering in Health and Medicine. doi: 10.1109/JTEHM.2021.3053172. Fulltekst i vitenarkiv Vis sammendrag

  Objective. Most of the previous studies of drone transport of blood samples examined normal blood samples transported under tranquil air conditions. We studied the effects of 1- and 2-hour drone flights using random vibration and turbulence simulation (10-30 g-force) on blood samples from 16 healthy volunteers and 74 patients with varying diseased. Methods: Thirty-two of the most common analytes were tested. For biochemical analytes, we used plasma collected in lithium heparin tubes with and without separator gel. Gel samples were analyzed for the effect of separation by centrifugation before or after turbulence. Turbulence was simulated in an LDS V8900 high-force shaker using random vibration (range, 5-200 Hz), with samples randomly allocated to 1- or 2-hour flights with 25 or 50 episodes of turbulence from 10 to 30 G. Results: For all hematologic and most biochemical analytes, test results before and after turbulence exposure were similar (bias <; 12%, intercepts <; 10%). However, aspartate aminotransferase, folate, lactate dehydrogenase and lipid index increased significantly in samples separated by gel and centrifugation prior to vibration and turbulence test. These changes increased form 10 G to 30 G, but were not observed when the samples were separated after vibration and turbulence. Conclusions: Whole blood showed little vulnerability to turbulence, whereas plasma samples separated from blood cells by gel may be significantly influenced by turbulence when separated by spinning before the exposure. Centrifugation of plasma samples collected in tubes with separator gel should be avoided before drone flights that could be subject to turbulence.

• Bornstedt, Mette Eskild; Gjerlaugsen, Nina; Olstad, Ole Kristoffer; Berg, Jens Petter; Bredahl, May K. Lyamouri & Thorsby, Per Medb?e (2020). Vitamin D metabolites influence expression of genes concerning cellular viability and function in insulin producing ¦Â-cells (INS1E). Gene. ISSN 0378-1119. 746:144649, s. 1¨C8. doi: 10.1016/j.gene.2020.144649. Fulltekst i vitenarkiv Vis sammendrag

  Background Studies have shown that vitamin D can enhance glucose-stimulated insulin secretion (GSIS) and change the expression of genes in pancreatic ¦Â-cells. Still the mechanisms linking vitamin D and GSIS are unknown. Material and methods We used an established ¦Â-cell line, INS1E. INS1E cells were pre-treated with 10 nM 1,25(OH)2vitamin D or 10 nM 25(OH)vitamin D for 72 h and stimulated with 22 mM glucose for 60 min. RNA was extracted for gene expression analysis. Results Expression of genes affecting viability, apoptosis and GSIS changed after pre-treatment with both 1,25(OH)2vitamin D and 25(OH)vitamin D in INS1E cells. Stimulation with glucose after pre-treatment of INS1E cells with 1,25(OH)2vitamin D resulted in 181 differentially expressed genes, whereas 526 genes were differentially expressed after pre-treatment with 25(OH)vitamin D. Conclusion Vitamin D metabolites may affect pancreatic ¦Â-cells and GSIS through changed gene expression for genes involved in ¦Â-cell function and viability.

• Eieland, Alexander K.; Normann, Kjersti R.; Sundaram, Arvind Y. M.; Nyman, Tuula A.; ?ystese, Kristin A. B. & Lekva, Tove [Vis alle 9 forfattere av denne artikkelen] (2020). Distinct pattern of endoplasmic reticulum protein processing and extracellular matrix proteins in functioning and silent corticotroph pituitary adenomas. Cancers. 12(10), s. 1¨C20. doi: 10.3390/cancers12102980. Fulltekst i vitenarkiv
• Mitlid-Mork, Birgitte; Bowe, Sophie; Gran, Jon Michael; Bolstad, Nils; Berg, Jens Petter & Redman, Christopher W.G. [Vis alle 8 forfattere av denne artikkelen] (2020). Maternal placental growth factor and soluble fms-like tyrosine kinase-1 reference ranges in post-term pregnancies: A prospective observational study. PLOS ONE. 15:e0240473(10), s. 1¨C14. doi: 10.1371/journal.pone.0240473. Fulltekst i vitenarkiv
• Brusletto, Berit Sletbakk; L?berg, Else Marit; Hellerud, Bernt C; Goverud, Ingeborg L?stegaard; Berg, Jens Petter & Olstad, Ole Kristoffer [Vis alle 9 forfattere av denne artikkelen] (2020). Extensive changes in transcriptomic ¡°fingerprints¡± and immunological cells in the large organs of patients dying of acute septic shock and multiple organ failure caused by Neisseria meningitidis. Frontiers in Cellular and Infection Microbiology. 10:42, s. 1¨C30. doi: 10.3389/fcimb.2020.00042. Fulltekst i vitenarkiv
• Atukunda, Prudence; Muhoozi, Grace Kyamazima Mehangye; Diep, Lien My; Berg, Jens Petter; Westerberg, Ane Cecilie & Iversen, Per Ole (2020). The association of urine markers of iodine intake with development and growth among children in rural Uganda: A secondary analysis of a randomised education trial. Public Health Nutrition (PHN). ISSN 1368-9800. s. 1¨C10. doi: 10.1017/S1368980020001603. Fulltekst i vitenarkiv
• Beitland, Sigrid; Nakstad, Espen Rostrup; Berg, Jens Petter; Siebke, Anne-Marie; Brusletto, Berit Sletbakk & Brunborg, Cathrine [Vis alle 8 forfattere av denne artikkelen] (2019). Urine ¦Â-2-Microglobulin, Osteopontin, and Trefoil Factor 3 May Early Predict Acute Kidney Injury and Outcome after Cardiac Arrest. Critical Care Research and Practice. ISSN 2090-1305. 2019. doi: 10.1155/2019/4384796. Fulltekst i vitenarkiv
• N?ss-Andresen, Marthe-Lise; Eggemoen, ?se Ruth; Berg, Jens Petter; Falk, Ragnhild S?rum & Jenum, Anne Karen (2019). Serum ferritin, soluble transferrin receptor, and total body iron for the detection of iron deficiency in early pregnancy: A multiethnic population-based study with low use of iron supplements. American Journal of Clinical Nutrition. ISSN 0002-9165. 109(3), s. 566¨C575. doi: 10.1093/ajcn/nqy366. Fulltekst i vitenarkiv
• Jansen, Aina; Berg, Jens Petter; Klungs?yr, Ole; M¨¹ller, Mette Helen Bj?rge; Lyche, Jan Ludvig & Aaseth, Jan (2019). The Influence of Persistent Organic Pollutants on Thyroidal, Reproductive and Adrenal Hormones After Bariatric Surgery. Obesity Surgery. ISSN 0960-8923. doi: 10.1007/s11695-019-04273-w. Vis sammendrag

  Persistent organic pollutants (POPs) including organochlorine pesticides, polychlorinated biphenyls (PCBs), and per- and polyfluoroalkylated substances (PFASs) are suspected endocrine disruptors. AIM: To evaluate the associations between POPs and thyroidal, reproductive, and adrenal hormones in a study population treated with bariatric surgery. METHODS: Blood samples from a cohort of 63 participants before and 1 year after bariatric surgery were analyzed for 16 lipophilic POPs, 17 PFASs, and thyroidal, reproductive, and adrenal hormones. Participants reporting relevant medical conditions or interfering medication were excluded, and plausible confounders were corrected for in multiple regression analyses. RESULTS: Free thyroxine (fT4) showed a significant decrease from preoperative to postoperative follow-up, and regression analyses demonstrated that p,p'-dichlorodiphenyldichloroethylene (p,p-DDE) was inversely associated with the ratio free triiodothyronine/free thyroxine (fT3/fT4). Testosterone concentrations in male participants increased significantly in the study period, and sex hormone-binding globulin (SHBG) increased in both gender. Regression analyses showed positive associations between increased levels of lipophilic POPs and the raised postoperative testosterone and SHBG concentrations in males. For females, an inverse association between the sum perfluoroalkyl carboxylic acids (¦²PFCA) and SHBG was seen. Regression analyses of postoperative serum cortisol concentrations on changes in hexachlorobenzene (HCB) showed a non-significant inverse association. CONCLUSION: The results suggest that POPs may have an influence on the hypothalamic-pituitary-thyroid (HPT) and the hypothalamic-pituitary-gonadal (HPG) axes after bariatric surgery. Because of small sample sizes and discrepancy in the sampling time points pre- and postoperatively, the observed hormonal impacts of POPs must be interpreted as associative and not causative. Further studies are needed to confirm the findings.

• Gopinathan, Unni; Redalen, Kathrine; Siebke, Anne-Marie; Kierulf, Peter; Brandtz?g, Petter & Ree, Anne Hansen [Vis alle 8 forfattere av denne artikkelen] (2018). Large-scale reduction of tyrosine kinase activities in human monocytes stimulated in vitro with N. meningitidis. PLOS ONE. 13(1). doi: 10.1371/journal.pone.0181912. Fulltekst i vitenarkiv
• ?ystese, Kristin Astrid Berland; Berg, Jens Petter; Normann, Kjersti Ringvoll; Zucknick, Manuela; Casar-Borota, Olivera & Bollerslev, Jens (2018). The role of E and N-cadherin in the postoperative course of gonadotroph pituitary tumours. Endocrine. ISSN 1355-008X. 62(2), s. 351¨C360. doi: 10.1007/s12020-018-1679-0.
• Hassel, Bj?rnar; Mariussen, Espen; Idland, Ane-Victoria; Dahl, Gry Tors?ter; R?der, Johan & Frihagen, Frede Jon [Vis alle 10 forfattere av denne artikkelen] (2018). CSF sodium at toxic levels precedes delirium in hip fracture patients. Neurotoxicology. ISSN 0161-813X. 69(December), s. 11¨C16. doi: 10.1016/j.neuro.2018.08.010.
• Pasovic, Lara; Utheim, Tor Paaske; Reppe, Sjur; Khan, Ayyad Ahmad Zartasht; Jackson, Catherine & Thiede, Bernd [Vis alle 9 forfattere av denne artikkelen] (2018). Improvement of storage medium for cultured human retinal pigment epithelial cells using factorial design. Scientific Reports. 8(1). doi: 10.1038/s41598-018-24121-8. Fulltekst i vitenarkiv Vis sammendrag

  Storage of human retinal pigment epithelium (hRPE) can contribute to the advancement of cell-based RPE replacement therapies. The present study aimed to improve the quality of stored hRPE cultures by identifying storage medium additives that, alone or in combination, contribute to enhancing cell viability while preserving morphology and phenotype. hRPE cells were cultured in the presence of the silk protein sericin until pigmentation. Cells were then stored for 10 days in storage medium plus sericin and either one of 46 diferent additives. Individual efects of each additive on cell viability were assessed using epifuorescence microscopy. Factorial design identifed promising additive combinations by extrapolating their individual efects. Supplementing the storage medium with sericin combined with adenosine, L-ascorbic acid and allopurinol resulted in the highest cell viability (98.6 ¡À 0.5%) after storage for three days, as measured by epifuorescence microscopy. Flow cytometry validated the fndings. Proteomics identifed 61 upregulated and 65 downregulated proteins in this storage group compared to the unstored control. Transmission electron microscopy demonstrated the presence of melanosomes after storage in the optimized medium. We conclude that the combination of adenosine, L-ascorbic acid, allopurinol and sericin in minimal essential medium preserves RPE pigmentation while maintaining cell viability during storage.

• Aass, Hans Christian Dalsbotten; Hellum, Marit Synn?ve; Siebke, Anne-Marie; Brandtz?g, Petter; Berg, Jens Petter & ?vsteb?, Reidun [Vis alle 7 forfattere av denne artikkelen] (2018). Whole-blood incubation with the Neisseria meningitidis lpxL1 mutant induces less pro-inflammatory cytokines than the wild type, and IL-10 reduces the MyD88-dependent cytokines. Innate Immunity. ISSN 1753-4259. 24(2), s. 101¨C111. doi: 10.1177/1753425917749299. Fulltekst i vitenarkiv
• Hellum, Marit Synn?ve; Siebke, Anne-Marie; Berg, Jens Petter; Brandtz?g, Petter; ?vsteb?, Reidun & Henriksson, Carola (2017). The Neisseria meningitidis lpxL1 mutant induces less tissue factor expression and activity in primary human monocytes and monocyte-derived microvesicles than the wild type meningococcus. Innate Immunity. ISSN 1753-4259. 23(2), s. 196¨C205. doi: 10.1177/1753425916684201.
• ?ystese, Kristin Astrid Berland; Casar-Borota, Olivera; Normann, Kjersti Ringvoll; Zucknick, Manuela; Berg, Jens Petter & Bollerslev, Jens (2017). Estrogen Receptor ¦Á, a Sex-Dependent Predictor of Aggressiveness in Nonfunctioning Pituitary Adenomas: SSTR and Sex Hormone Receptor Distribution in NFPA. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 102(9), s. 3581¨C3590. doi: 10.1210/jc.2017-00792.
• Vistnes, Maria; Tapia, German; M?rild, Karl Staffan; Midttun, ?ivind; Ueland, Per Magne & Viken, Marte K [Vis alle 14 forfattere av denne artikkelen] (2017). Plasma immunological markers in pregnancy and cord blood: A possible link between macrophage chemo-attractants and risk of childhood type 1 diabetes. American journal of reproductive immunology. ISSN 1046-7408. 79(3). doi: 10.1111/aji.12802.
• Gopinathan, Unni; ?vsteb?, Reidun; Brusletto, Berit Sletbakk; Olstad, Ole Kristoffer; Kierulf, Peter & Brandtz?g, Petter [Vis alle 7 forfattere av denne artikkelen] (2017). Transcriptomic data from two primary cell models stimulating human monocytes suggest inhibition of oxidative phosphorylation and mitochondrial function by N. meningitidis which is partially up-regulated by IL-10. BMC Immunology. 18:46, s. 1¨C17. doi: 10.1186/s12865-017-0229-5.
• Waage, Christin; Jenum, Anne Karen; Mdala, Ibrahimu; Berg, Jens Petter; Richardsen, K?re R?nn & Birkeland, K?re I. (2017). Associations between gestational diabetes mellitus and elevated HbA1c early postpartum in a multi-ethnic population. Primary Care Diabetes. ISSN 1751-9918. 11(2), s. 132¨C139. doi: 10.1016/j.pcd.2016.09.007. Vis sammendrag

  Aims To investigate the prevalence of elevated HbA1c 14 weeks postpartum in different ethnic groups and in women with and without gestational diabetes mellitus (GDM) in the index pregnancy and to explore demographic and biological factors from early pregnancy associated with elevated HbA1c (HbA1c ¡Ý5.7% (¡Ý39 mmol/mol)) postpartum. Methods From a cohort study in Oslo, Norway, we included 570 pregnant women, examined in gestational week 15, 28, and 14 weeks postpartum. The association between elevated HbA1c and demographic and biological factors were assessed by logistic regression analyses. Results The prevalence of elevated HbA1c postpartum was 23% in the total population, 15% among Western Europeans and 28% among women with ethnic minority background (p < 0.01). In ethnic minorities elevated HbA1c was found in 39% of women with recent GDM diagnosed by the World Health Organization 2013 criteria and in 21% of women without GDM (p < 0.01), compared to 22% and 13% in Western Europeans (p = 0.11). We found independent associations between elevated HbA1c and ethnic minority background (OR 2.0, 95% CI 1.27, 3.18), and GDM (OR 2.04, 95% CI 1.35, 3.10) (p < 0.01). Conclusions The prevalence of elevated HbA1c postpartum was 23%, and significantly higher among women with ethnic minority background irrespective of GDM.

• J?rgenrud, Benedicte Marie; Stene, Lars Christian; Tapia, German; B??s, H?kon; Pepaj, Milaim & Berg, Jens Petter [Vis alle 10 forfattere av denne artikkelen] (2017). Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study. Pediatric Diabetes. ISSN 1399-543X. 18, s. 111¨C119. doi: 10.1111/pedi.12360. Vis sammendrag

  Aims The aim of this study was to investigate the longitudinal plasma metabolic profiles in healthy infants and the potential association with breastfeeding duration and islet autoantibodies predictive of type 1 diabetes. Method Up to four longitudinal plasma samples from age 3 months from case children who developed islet autoimmunity (n?=?29) and autoantibody-negative control children (n?=?29) with the HLA DR4-DQ8/DR3-DQ2 genotype were analyzed using two-dimensional gas chromatography coupled to a time-of-flight mass spectrometer for detection of small polar metabolites. Results Plasma metabolite levels were found to depend strongly on age, with fold changes varying up to 50% from age 3 to 24 months (p?<?0.001 after correction for multiple testing). Tyrosine levels tended to be lower in case children, but this was not significant after correction for multiple testing. Ornithine levels were lower in case children compared with the controls at the time of seroconversion, but the difference was not statistically significant after correcting for multiple testing. Breastfeeding for at least 3?months as compared with shorter duration was associated with higher plasma levels of isoleucine, and lower levels of methionine and 3,4-dihydroxybutyric acid at 3 months of age. Conclusions Plasma levels of several small, polar metabolites changed with age during early childhood, independent of later islet autoimmunity status and sex. Breastfeeding was associated with higher levels of branched-chain amino acids, and lower levels of methionine and 3,4-dihydroxybutyric acid.

• Klingenberg, Olav; Furuset, Torill; Hestbr?ten, Camilla R?ising; Hallberg, Marit Hansen; Steiro, Astrid & Orset, Iren R?stbakken [Vis alle 7 forfattere av denne artikkelen] (2017). HbA1c analysis by capillary electrophoresis?comparison with chromatography and an immunological method. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 77(6), s. 458¨C464. doi: 10.1080/00365513.2017.1338747. Fulltekst i vitenarkiv
• Brusletto, Berit Sletbakk; Hellerud, Bernt C; L?berg, Else Marit; Goverud, Ingeborg L?stegaard; Vege, ?shild & Berg, Jens Petter [Vis alle 8 forfattere av denne artikkelen] (2017). Traceability and distribution of Neisseria meningitidis DNA in archived post mortem tissue samples from patients with systemic meningococcal disease. BMC Clinical Pathology. 17(1). doi: 10.1186/s12907-017-0049-9.
• Beitland, Sigrid; Waldum-Grevbo, B?rd Endre; Nakstad, Espen Rostrup; Berg, Jens Petter; Siebke, Anne-Marie & Brusletto, Berit Sletbakk [Vis alle 9 forfattere av denne artikkelen] (2016). Urine biomarkers give early prediction of acute kidney injury and outcome after outof- hospital cardiac arrest. Critical Care. ISSN 1364-8535. 20(1). doi: 10.1186/s13054-016-1503-2.
• Hov, Karen Roksund; Berg, Jens Petter; Frihagen, Frede Jon; R?der, Johan; Hall, Roanna J. & Wyller, Torgeir Bruun [Vis alle 7 forfattere av denne artikkelen] (2016). Blood-cerebrospinal fluid barrier integrity in delirium determined by Q-Albumin. Dementia and Geriatric Cognitive Disorders. ISSN 1420-8008. 41(3-4), s. 192¨C198. doi: 10.1159/000443789.
• Normann, Kjersti Ringvoll; ?ystese, Kristin Astrid Berland; Berg, Jens Petter; Lekva, Tove; Berg-Johnsen, Jon & Bollerslev, Jens [Vis alle 7 forfattere av denne artikkelen] (2016). Selection and validation of reliable reference genes for RT-qPCR analysis in a large cohort of pituitary adenomas. Molecular and Cellular Endocrinology. ISSN 0303-7207. 437, s. 183¨C189. doi: 10.1016/j.mce.2016.08.030.
• Sachse, Daniel; Solev?g, Anne Lee; Berg, Jens Petter & Nakstad, Britt (2016). The role of plasma and urine metabolomics in identifying new biomarkers in severe newborn asphyxia: A study of asphyxiated newborn pigs following cardiopulmonary resuscitation. PLOS ONE. 11:e0161123(8). doi: 10.1371/journal.pone.0161123. Fulltekst i vitenarkiv
• Kristensen, Gunn Berit Berge; Rustad, P?l; Berg, Jens Petter & Aakre, Kristin (2016). Analytical bias exceeding desirable quality goal in 4 out of 5 common immunoassays: Results of a native single serum sample external quality assessment program for cobalamin, folate, ferritin, thyroid-stimulating hormone, and free t4 analyses. Clinical Chemistry. ISSN 0009-9147. 62(9), s. 1255¨C1263. doi: 10.1373/clinchem.2016.258962.
• Kringen, Marianne K.; Stormo, Camilla; Berg, Jens Petter; Terry, Sharon F.; Vocke, Christine M. & Rizvi, Samar [Vis alle 8 forfattere av denne artikkelen] (2015). Copy number variation in the ATP-binding cassette transporter ABCC6 gene and ABCC6 pseudogenes in patients with pseudoxanthoma elasticum. Molecular Genetics & Genomic Medicine. ISSN 2324-9269. 3(3), s. 233¨C237. doi: 10.1002/mgg3.137. Vis sammendrag

  Single mutations in the ATP-binding cassette transporter (ABCC6) gene (OMIM 603234) are known to cause the rare autosomal recessive disease pseudoxanthoma elasticum (PXE). Recently, we have found that copy number variations (CNVs) in pseudogenes of the ABCC6 gene are quite common. The aim of this study was to investigate the frequency and possible contribution of CNV in ABCC6 and its pseudogenes in PXE. Genomic DNA from 212 PXE individuals were examined for copy number by pyrosequencing and quantitative polymerase chain reaction (PCR) and compared with healthy individuals. The frequency of PXE individuals with any CNV was higher than in healthy individuals. The majority of variation comprised known and possibly new deletions in the ABCC6 gene and duplications of the ABCC6P1 and ABCC6P2 genes. ABCC6 deletions and ABCC6P2 duplications were not observed in 142 healthy individuals. In conclusion, by pyrosequencing and quantitative PCR, we were able to detect known and possibly new deletions in the ABCC6 gene that may have caused the PXE phenotype. Pyrosequencing may be used in PXE patients who have obtained incomplete genotype from conventional techniques. The frequency of ABCC6P2 pseudogene duplication was more common in PXE patients than healthy individuals and may affect the PXE phenotype.

• Landr?, Nils Inge; Jonassen, Rune; Clark, Luke; Foss, Kari Bente; Aker, Martin & B?, Ragnhild [Vis alle 9 forfattere av denne artikkelen] (2015). Serotonin transporter polymorphisms predict response inhibition in healthy volunteers. Neuroscience Letters. ISSN 0304-3940. 584, s. 109¨C112. doi: 10.1016/j.neulet.2014.10.006.
• Reppe, Sjur; Noer, Agate; Grimholt, Runa Marie; Halldorsson, Bjarni V; Medina-Gomez, Carolina & Gautvik, Vigdis Teig [Vis alle 16 forfattere av denne artikkelen] (2015). Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women. Journal of Bone and Mineral Research. ISSN 0884-0431. 30(2), s. 249¨C256. doi: 10.1002/jbmr.2342.
• Lekva, Tove; Berg, Jens Petter; Lyle, Robert; Heck, Ansgar; Bollerslev, Jens & Ueland, Thor (2015). Alternative splicing of placental lactogen (CSH2) in somatotroph pituitary adenomas. Neuro - endocrinology letters. ISSN 0172-780X. 36(2), s. 136¨C142. Vis sammendrag

  OBJECTIVES: Somatotroph adenomas secrete supraphysiological amounts of GH, causing acromegaly. We have previously shown epithelial splicing regulator 1 (ESRP1) to play a role in epithelial mesenchymal transition (EMT) progression in these adenomas and account for poor treatment response. We evaluated if the mRNA levels of the GH/CSH gene cluster in somatotroph adenomas are associated with an epithelial phenotype and response to SA treatment. METHODS: We investigated the associations between ESRP1 and the growth hormone/chorionic somatomammotropin (GH/CSH) gene cluster by RNA sequencing (RNAseq). CSH2 isoform 3 mRNA was further evaluated in 65 somatotroph adenomas and associations with disease severity and treatment response. RESULTS: mRNA for all genes in the GH/CSH cluster were expressed, however, only chorionic somatomammotropin 2/placental lactogen 2 (CSH2) displayed an alternative splicing pattern. CSH2 isoform 3 was associated with a dense granulation pattern and an epithelial phenotype with high levels of ESRP1 and E-cadherin expression. Further, CSH2 isoform 3 was associated with reduced serum GH and IGF-I levels after somatostatin analog treatment. CONCLUSIONS: Attenuated CSH2 isoform 3 was associated with mesenchymal phenotype and a blunted clinical response to somatostatin analog treatment in patients with acromegaly.

• Gopinathan, Unni; Brusletto, Berit Sletbakk; Olstad, Ole Kristoffer; Kierulf, Peter; Berg, Jens Petter & Brandtz?g, Petter [Vis alle 7 forfattere av denne artikkelen] (2015). IL-10 immunodepletion from meningococcal sepsis plasma induces extensive changes in gene expression and cytokine release in stimulated human monocytes. Innate Immunity. ISSN 1753-4259. 21(4), s. 429¨C449. doi: 10.1177/1753425914547743.
• Hellum, Marit Synn?ve; ?vsteb?, Reidun; Brusletto, Berit Sletbakk; Berg, Jens Petter; Brandtz?g, Petter & Henriksson, Carola (2014). Microparticle-associated tissue factor activity correlates with plasma levels of bacterial lipopolysaccharides in meningocoocal septic shock. Thrombosis Research. ISSN 0049-3848. 133(3), s. 507¨C514. doi: 10.1016/j.thromres.2013.12.031.
• Stormo, Camilla; Kristiansen, Marianne; Lyle, Robert; Olstad, Ole Kristoffer; Sachse, Daniel & Berg, Jens Petter [Vis alle 7 forfattere av denne artikkelen] (2014). RNA-sequencing analysis of HepG2 cells treated with atorvastatin. PLOS ONE. 9:e0105836(8). doi: 10.1371/journal.pone.0105836. Fulltekst i vitenarkiv
• Vik?ren, Thea Berge; Berg, Jens Petter & Berg, Tore Julsrud (2014). Feilkilder ved bruk av hemoglobin A1C. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 134(4), s. 417¨C421. doi: 10.4045/tidsskr.13.0938.
• Moltu, Sissel; Sachse, Daniel; Blakstad, Elin Wahl; Str?mmen, Kenneth; Nakstad, Britt & Almaas, Astrid [Vis alle 14 forfattere av denne artikkelen] (2014). Urinary metabolite profiles in premature infants show early postnatal metabolic adaption and maturation. Nutrients. 6(5), s. 1913¨C1930. doi: 10.3390/nu6051913.
• Steen, Nils Eiel; Methlie, Paal; Lorentzen, Steinar; Dieset, Ingrid; Aas, Monica & Nerhus, Mari [Vis alle 11 forfattere av denne artikkelen] (2014). Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders. Journal of Psychiatric Research. ISSN 0022-3956. 52(1), s. 57¨C62. doi: 10.1016/j.jpsychires.2014.01.017.
• Sachse, Daniel; B?rug, Anne Bergljot; Sletner, Line; Birkeland, K?re I.; Nakstad, Britt & Jenum, Anne Karen [Vis alle 7 forfattere av denne artikkelen] (2014). Urine NMR metabolomics analysis of breastfeeding biomarkers during and after pregnancy in a large prospective cohort study. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 74(3), s. 264¨C272. doi: 10.3109/00365513.2014.884240.
• Lekva, Tove; Berg, Jens Petter; Heck, Ansgar; Fougner, Stine Lyngvi; Olstad, Ole Kristoffer & Ringstad, Geir Andre [Vis alle 8 forfattere av denne artikkelen] (2013). Attenuated RORC expression in the presence of EMT progression in somatotroph adenomas following treatment with somatostatin analogs is associated with poor clinical recovery. PLOS ONE. 8(6). doi: 10.1371/journal.pone.0066927.
• Lekva, Tove; Berg, Jens Petter; Lyle, Robert; Heck, Ansgar; Ringstad, Geir Andre & Olstad, Ole Kristoffer [Vis alle 10 forfattere av denne artikkelen] (2013). Epithelial Splicing Regulator Protein 1 and Alternative Splicing in Somatotroph Adenomas. Endocrinology. ISSN 0013-7227. 154(9), s. 3331¨C3343. doi: 10.1210/en.2013-1051.
• Berg, Jens Petter (2013). Hba1c as a diagnostic tool in diabetes mellitus. Norsk Epidemiologi. ISSN 0803-2491. 23(1), s. 5¨C8. doi: 10.5324/nje.v23i1.1596.
• Evang, Johan Arild; Bollerslev, Jens; Casar-Borota, Olivera; Lekva, Tove; Ramm-Pettersen, Jon-Terje & Berg, Jens Petter (2013). Different levels of various glucocorticoid-regulated genes in corticotroph adenomas. Endocrine. ISSN 1355-008X. 44(1), s. 220¨C227. doi: 10.1007/s12020-012-9871-0.
• Reppe, Sjur; Sachse, Daniel; Olstad, Ole Kristoffer; Gautvik, Vigdis Teig; Sanderson, Paul & Datta, Harish K [Vis alle 8 forfattere av denne artikkelen] (2013). Identification of transcriptional macromolecular associations in human bone using browser based in silico analysis in a giant correlation matrix. Bone. ISSN 8756-3282. 53(1), s. 69¨C78. doi: 10.1016/j.bone.2012.11.015.
• Sakhi, Amrit Kaur; Berg, Jens Petter & Berg, Tore Julsrud (2013). Glyoxalase 1 enzyme activity in erythrocytes and Ala111Glu polymorphism in type 1-diabetes patients. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 73(2), s. 175¨C181. doi: 10.3109/00365513.2013.765028.
• Moltu, Sissel; Str?mmen, Kenneth; Blakstad, Elin Wahl; Almaas, Astrid; Westerberg, Ane Cecilie & Br?kke, Kristin [Vis alle 13 forfattere av denne artikkelen] (2013). Enhanced feeding in very-low-birth-weight infants may cause electrolyte disturbances and septicemia - A randomized, controlled trial. Clinical Nutrition. ISSN 0261-5614. 32(2), s. 207¨C212. doi: 10.1016/j.clnu.2012.09.004.
• Jonassen, Rune; Endestad, Tor; Neumeister, Alexander; Haug, Kari Bente Foss; Berg, Jens Petter & Landr?, Nils Inge (2012). Serotonin Transporter Polymorphism Modulates N-Back Task Performance and fMRI BOLD Signal Intensity in Healthy Women. PLOS ONE. 7(1). doi: 10.1371/journal.pone.0030564.
• Jonassen, Rune; Endestad, Tor; Neumeister, Alexander; Foss, Kari Bente; Berg, Jens Petter & Landr?, Nils Inge (2012). The effects of the serotonin transporter polymorphism and age on frontal white matter integrity in healthy adult women. Frontiers in Human Neuroscience. 6. doi: 10.3389/fnhum.2012.00019.
• Gopinathan, Unni; ?vsteb?, Reidun; Olstad, Ole Kristoffer; Brusletto, Berit Sletbakk; Aass, Hans Christian & Kierulf, Peter [Vis alle 8 forfattere av denne artikkelen] (2012). Global Effect of Interleukin-10 on the Transcriptional Profile Induced by Neisseria meningitidis in Human Monocytes. Infection and Immunity. ISSN 0019-9567. 80(11), s. 4046¨C4054. doi: 10.1128/IAI.00386-12.
• Sachse, Daniel; Sletner, Line; M?rkrid, Kjersti; Jenum, Anne Karen; Birkeland, K?re I. & Rise, Frode [Vis alle 8 forfattere av denne artikkelen] (2012). Metabolic Changes in Urine during and after Pregnancy in a Large, Multiethnic Population-Based Cohort Study of Gestational Diabetes. PLOS ONE. 7(12). doi: 10.1371/journal.pone.0052399. Fulltekst i vitenarkiv Vis sammendrag

  This study aims to identify novel markers for gestational diabetes (GDM) in the biochemical profile of maternal urine using NMR metabolomics. It also catalogs the general effects of pregnancy and delivery on the urine profile. Urine samples were collected at three time points (visit V1: gestational week 8¨C20; V2: week 28¡À2; V3:10¨C16 weeks post partum) from participants in the STORK Groruddalen program, a prospective, multiethnic cohort study of 823 healthy, pregnant women in Oslo, Norway, and analyzed using 1H-NMR spectroscopy. Metabolites were identified and quantified where possible. PCA, PLS-DA and univariate statistics were applied and found substantial differences between the time points, dominated by a steady increase of urinary lactose concentrations, and an increase during pregnancy and subsequent dramatic reduction of several unidentified NMR signals between 0.5 and 1.1 ppm. Multivariate methods could not reliably identify GDM cases based on the WHO or graded criteria based on IADPSG definitions, indicating that the pattern of urinary metabolites above micromolar concentrations is not influenced strongly and consistently enough by the disease. However, univariate analysis suggests elevated mean citrate concentrations with increasing hyperglycemia. Multivariate classification with respect to ethnic background produced weak but statistically significant models. These results suggest that although NMR-based metabolomics can monitor changes in the urinary excretion profile of pregnant women, it may not be a prudent choice for the study of GDM.

• Kristiansen, Marianne; Stormo, Camilla; Grimholt, Runa Marie; Berg, Jens Petter & Piehler, Armin (2012). Copy number variations of the ATP-binding cassette transporter ABCC6 gene and its pseudogenes. BMC Research Notes. 5. doi: 10.1186/1756-0500-5-425.
• Jorde, Rolf; Schirmer, Henrik; Wilsgaard, Tom; Joakimsen, Ragnar Martin; Mathiesen, Ellisiv B. & Nj?lstad, Inger [Vis alle 11 forfattere av denne artikkelen] (2012). Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Troms? Study. PLOS ONE. 7(5). doi: 10.1371/journal.pone.0037295. Fulltekst i vitenarkiv Vis sammendrag

  Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these SNPs and health. DNA was prepared from subjects who participated in the fourth survey of the Troms? Study in 1994¨C1995 and who were registered with the endpoints MI, T2DM, cancer or death as well as a randomly selected control group. The endpoint registers were complete up to 2007¨C2010. Genotyping was performed for 17 SNPs related to the serum 25(OH)D level. A total of 9528 subjects were selected for genetic analyses which were successfully performed for at least one SNP in 9471 subjects. Among these, 2025 were registered with MI, 1092 with T2DM, 2924 with cancer and 3828 had died. The mean differences in serum 25(OH)D levels between SNP genotypes with the lowest and highest serum 25(OH)D levels varied from 0.1 to 7.8 nmol/L. A genotype score based on weighted risk alleles regarding low serum 25(OH)D levels was established. There was no consistent association between the genotype score or individuals SNPs and MI, T2DM, cancer, mortality or risk factors for disease. However, for rs6013897 genotypes (located at the 24-hydroxylase gene (CYP24A1)) there was a significant association with breast cancer (P<0.05). Our results do not support nor exclude a causal relationship between serum 25(OH)D levels and MI, T2DM, cancer or mortality, and our observation on breast cancer needs confirmation. Further genetic studies are warranted, particularly in populations with vitamin D deficiency.

• Hellum, Marit Synn?ve; ?vsteb?, Reidun; Siebke, Anne-Marie; Berg, Jens Petter; Brandtz?g, Petter & Henriksson, Carola (2012). Microparticle-associated tissue factor activity measured with the Zymuphen MP-TF kit and the calibrated automated thrombogram assay. Blood Coagulation and Fibrinolysis. ISSN 0957-5235. 23(6), s. 520¨C526. doi: 10.1097/MBC.0b013e328354a256.
• ?vsteb?, Reidun; Aass, Hans Christian; Foss, Kari Bente; Siebke, Anne-Marie; Gopinathan, Unni & Kierulf, Peter [Vis alle 9 forfattere av denne artikkelen] (2012). LPS from Neisseria meningitidis is crucial for inducing monocyte- and microparticle-associated tissue factor activity but not for tissue factor expression. Innate Immunity. ISSN 1753-4259. 18(4), s. 580¨C591. doi: 10.1177/1753425911428230.
• Stormo, Camilla; Kristiansen, Marianne; Grimholt, Runa Marie; Berg, Jens Petter & Piehler, Armin (2012). A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus. BMC Molecular Biology. 13. doi: 10.1186/1471-2199-13-29.
• Lekva, Tove; Berg, Jens Petter; Fougner, Stine Lyngvi; Olstad, Ole Kristoffer; Ueland, Thor & Bollerslev, Jens (2012). Gene Expression Profiling Identifies ESRP1 as a Potential Regulator of Epithelial Mesenchymal Transition in Somatotroph Adenomas from a Large Cohort of Patients with Acromegaly. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 97(8), s. E1506¨CE1514. doi: 10.1210/jc.2012-1760.
• Fougner, Stine Lyngvi; Borota, Olivera Casar; Heck, Ansgar; Berg, Jens Petter & Bollerslev, Jens (2012). Adenoma granulation pattern correlates with clinical variables and effect of somatostatin analogue treatment in a large series of patients with acromegaly. Clinical Endocrinology. ISSN 0300-0664. 76(1), s. 96¨C102. doi: 10.1111/j.1365-2265.2011.04163.x.
• Aass, Hans Christian D.; ?vsteb?, Reidun; Tr?seid, Anne-Marie S.; Kierulf, Peter; Berg, Jens Petter & Henriksson, Carola Elisabeth (2011). Fluorescent particles in the antibody solution result in false TF- and CD14-positive microparticles in flow cytometric analysis. Cytometry Part A. ISSN 1552-4922. 79A(12), s. 990¨C999. doi: 10.1002/cyto.a.21147.
• Evang, Johan Arild; Berg, Jens Petter; Borota, Olivera Casar; Lekva, Tove; Kristiansen, Marianne & Ramm-Pettersen, Jon-Terje [Vis alle 7 forfattere av denne artikkelen] (2011). Reduced levels of E-cadherin correlate with progression of corticotroph pituitary tumours. Clinical Endocrinology. ISSN 0300-0664. 75(6), s. 811¨C818. doi: 10.1111/j.1365-2265.2011.04109.x.
• Kristiansen, Marianne; Foss, Kari Bente; Grimholt, Runa Marie; Stormo, Camilla; Narum, Sigrid & Opdal, Mimi S. [Vis alle 12 forfattere av denne artikkelen] (2011). Genetic Variation of VKORC1 and CYP4F2 Genes Related to Warfarin Maintenance Dose in Patients with Myocardial Infarction. Journal of Biomedicine and Biotechnology. ISSN 1110-7243. 2011. doi: 10.1155/2011/739751.
• Steen, Nils Eiel; Lorentzen, Steinar; Barrett, Elisabeth Ann; Lagerberg, Trine Vik; Hope, Sigrun & Larsson, Sara [Vis alle 11 forfattere av denne artikkelen] (2011). Sex-specific cortisol levels in bipolar disorder and schizophrenia during mental challenge - Relationship to clinical characteristics and medication. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 35(4), s. 1100¨C1107. doi: 10.1016/j.pnpbp.2011.03.008.
• Lund, Terje; Svindland, Aud; Pepaj, Milaim; Jensen, Aase-Brith Ellefsen; Berg, Jens Petter & Kilhovd, Bente [Vis alle 7 forfattere av denne artikkelen] (2011). Fibrin(ogen) may be an important target for methylglyoxal-derived AGE modification in elastic arteries of humans. Diabetes & vascular disease research. ISSN 1479-1641. 8(4), s. 284¨C294. doi: 10.1177/1479164111416831.
• Berg, Jens Petter; Hanssen, Kristian Folkvord; Bjerve, Kristian S; Claudi, Tor; Dahl-J?rgensen, Knut & Rustad, P?l [Vis alle 8 forfattere av denne artikkelen] (2011). Standardisert hemoglobin A1C til diagnostisk bruk? Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 131(6), s. 565¨C6. doi: 10.4045/tidsskr.10.1160.

Se alle arbeider i NVA

• Hagve, Tor-Arne & Berg, Jens Petter (2019). Klinisk biokjemi og fysiologi, 6. utgave. Gyldendal Akademisk. ISBN 9788205527881. 464 s.
• Hagve, Tor-Arne & Berg, Jens Petter (2015). Klinisk biokjemi og fysiologi. Gyldendal Akademisk. ISBN 9788205463677. 443 s.
• Hagve, Tor-Arne & Berg, Jens Petter (2011). Klinisk biokjemi og fysiologi. Gyldendal Norsk Forlag A/S. ISBN 9788205399143. 448 s.

Se alle arbeider i NVA

• Storsul, Tanja; Berg, Jens Petter; Urdal, Henrik; Sivertsen, Gunnar & R?eggen, Vidar (2024). Fortsatt behov for forsker?involvering og kvalitets?orientering.
• Storsul, Tanja; Berg, Jens Petter; Urdal, Henrik; Sivertsen, Gunnar & R?eggen, Vidar (2023). Hvordan b?r framtidas indikator for publisering v?re? Khrono.no. ISSN 1894-8995.
• Mariampillai, Julian Eek; Halvorsen, Lene Vern?s; Larstorp, Anne Cecilie Kjeldsen; Heimark, Sondre; Waldum-Grevbo, B?rd & Kjeldsen, Sverre [Vis alle 10 forfattere av denne artikkelen] (2023). Diabetes og kronisk nyresykdom. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 143(12). doi: 10.4045/tidsskr.22.0822.
• Berg, Jens Petter & Gladhaug, Ivar Prydz (2020). Disputasen er en del av doktorgradsproven. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 140(9), s. 1¨C3. doi: 10.4045/tidsskr.20.0328.
• Berg, Jens Petter & Tazmini, Kiarash (2019). Utredning av sykdom i hypofysen, Klinisk biokjemi og fysiologi, 6. utgave. Gyldendal Akademisk. ISSN 9788205527881. s. 370¨C381.
• Berg, Jens Petter (2019). Utredning av sykdom i binyrene, Klinisk biokjemi og fysiologi, 6. utgave. Gyldendal Akademisk. ISSN 9788205527881. s. 382¨C393.
• Berg, Jens Petter & Gladhaug, Ivar Prydz (2019). Viktig at pr?veforelesningens hensikt blir oppfylt. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 139(16), s. 1534¨C1534. doi: 10.4045/tidsskr.19.0646.
• Schwettmann, Lutz; Berg, Jens Petter & Sandberg, Sverre (2018). HbA1c skal angis i mmol/mol. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 138(15), s. 1404¨C1405. doi: 10.4045/tidsskr.18.0633.
• Beitland, Sigrid; Nakstad, Espen Rostrup; Berg, Jens Petter; Tr?seid, Anne-Marie Siebke; Brusletto, Berit Sletbakk & Brunborg, Cathrine [Vis alle 7 forfattere av denne artikkelen] (2018). Urine biomarkers may early predict acute kidney injury and outcome after out-of-hospital cardiac arrest. Intensive Care Medicine Experimental. 6. doi: 10.1186/s40635-018-0201-6.
• M?rild, Karl; Vistnes, Maria; Tapia, German; Midttun, ?ivind; Ueland, Per Magne & Viken, Marte K [Vis alle 10 forfattere av denne artikkelen] (2017). Midpregnancy and cord blood immunologic biomarkers, HLA genotype, and pediatric celiac disease. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. 139(5), s. 1696¨C1698. doi: 10.1016/j.jaci.2016.10.016.
• Berg, Jens Petter (2015). Aromatase. I Godal, Anne Marit (Red.), Store norske leksikon (snl.no 2015). Store norske leksikon AS.
• Berg, Jens Petter (2015). antinukle?re faktorer. I Godal, Anne Marit (Red.), Store norske leksikon (snl.no 2015). Store norske leksikon AS.
• Berg, Jens Petter & Halse, Johan (2015). Fenylketonuri. I Godal, Anne Marit (Red.), Store norske leksikon (snl.no 2015). Store norske leksikon AS.
• Berg, Jens Petter (2015). Androstenedion. I Godal, Anne Marit (Red.), Store norske leksikon (snl.no 2015). Store norske leksikon AS.
• Berg, Jens Petter & ?ye, Ivar (2015). Dopingmidler. I Godal, Anne Marit (Red.), Store norske leksikon (snl.no 2015). Store norske leksikon AS.
• Berg, Jens Petter & ?ye, Ivar (2015). Dopingkontroll. I Godal, Anne Marit (Red.), Store norske leksikon (snl.no 2015). Store norske leksikon AS.
• Berg, Jens Petter & Opdahl, Helge (2015). Diabeteskoma. I Godal, Anne Marit (Red.), Store norske leksikon (snl.no 2015). Store norske leksikon AS.
• Berg, Jens Petter & Vaaler, Stein (2015). Diabetes. I Godal, Anne Marit (Red.), Store norske leksikon (snl.no 2015). Store norske leksikon AS.
• Vereshchagina, Elizaveta; Jensen, Geir Uri; Mielnik, Michal Marek; Berg, Jens Petter & ?vsteb?, Reidun (2015). A versatile fabrication and assembly approach for microfluidic capturing of extracellular vesicles. Vis sammendrag

  Cells communicate by means of "messengers" known as extracellular vesicles, i.e. small (30©\1000 nm) cell derived vesicles released from almost all eukaryotic cells into their extracellular environment and containing a variety of proteins and RNAs [1]. It has been foreseen that the next generation of biomarkers for disease diagnostics and prognostics may strongly depend on the vesicles being efficiently isolated, quantified and analyzed by e.g. reliable, high©\throughput and possibly easy©\to©\operate microfluidic devices. The results reported here extend the previously reported work by Chen et al. [2]: (i) the fabrication approach is based on silicon as a micromolding master, which offers better dimensional control and durability than SU©\8 masters, (ii) a staggered herringbone micromixer [3] is introduced in three different channel configurations , (iii) the device assembly allows straightforward integration of a large variety of surface chemistries by introducing prefunctionalized glass slides; (iv) individual functionalization of the glass slide and the PDMS replica prior to assembly permits combination of two differently biofunctionalized surfaces within the same fluidic device; (v) isolated extracellular vesicles can be accessed directly for a variety of post©\analyses by opening the device assembly.

• Jansen, Aina; Skaug, Marit Aralt; Berg, Jens Petter & Aaseth, Jan (2014). Overvekt og milj?gifter.
• Reppe, Sjur; Sachse, D.; Olstad, Ole Kristoffer; Gautvik, Vigdis Teig; Sanderson, P.L. & Datta, H.K. [Vis alle 8 forfattere av denne artikkelen] (2012). Identification of human transcriptional macromolecular associations using browser based in silico analysis in a giant correlation matrix. Bone. ISSN 8756-3282. 50, s. S109¨CS109. doi: 10.1016/j.bone.2012.02.334.
• Berg, Jens Petter (2011). Kapittel 17 Sykdommer i endokrine organer. I ?rn, Stein; Mjell, Johnny & Bach-Gansmo, Edvin (Red.), Sykdom og behandling. Gyldendal Akademisk. ISSN 9788205323605. s. 363¨C378.
• Storsul, Tanja; Berg, Jens Petter; Urdal, Henrik; Sivertsen, Gunnar & R?eggen, Vidar (2024). Kvalitet i vitenskapelig publisering. Organisering og innretning av publiseringsindikatoren, publiseringsstatistikken og kanalregisteret. En utredning for Kunnskapsdepartementet. Det nasjonale publiseringsutvalget.

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