Project
High throughput sequencing data of both DNA and RNA from multifocal prostate cancers generated by researchers at the Radium Hospital is in place. From these datasets a number of interesting genomic and transcriptomic alterations have been identified and the aim of the master project is to further investigate and validate their role in carcinogenesis, their heterogeneity in multifocal prostate cancer and their presence in liquid biopsies. Methods to be used include, but may not be limited to, PCR, real-time PCR, digital-droplet PCR, Rapid Amplification of cDNA Ends (RACE), and Sanger sequencing.
The Research group
As a master student you will be part of the Genome Biology Group at Department of Molecular Oncology located at the Norwegian Radium Hospital. Here a group of biologists and informaticians investigate cancer genomes and transcriptomes by integrating computational and laboratory based approaches to identify and characterize critical genes involved in the cancer development. The group is an associated member of the Centre of Excellence in Cancer Biomedicine and in the K. G. Jebsen Research Centre for Colorectal Cancer. Supervisors will be postdoc Marthe L?vf, group leader Rolf I. Skotheim, and head of department Ragnhild A. Lothe.