SPARK Norway projects

Active teams

A new antibody technology tailored for killing of antibiotic-resistant bacteria and cancer cells

• Project leader: Mirjam D¨¹rkoop, The Laboratory of Adaptive Immunity and Homeostasis, Centre of Excellence, Precision Immunotherapy Alliance (PRIMA), Department for Pharmacology, University of Oslo and Department for Immunology, Oslo University Hospital
• Team members: Professor Jan Terje Andersen, Stian Foss, Peter Skorpil (Inven2) and Kirsten Stangebye (Inven2)?

Nexus - Transforming Patient Care with a Novel Endoscopic Stent Solution

• Project leader: Magnus L?berg, Faculty of Medicine, University of Oslo
• Team member: Christer Julseth T?nnesen ?

Finalization and Testing of an Integrated Illumination Lightguide Prototype for Cryo-Retinal Surgery?

• Project leader: Goran Petrovski, Department of Ophthalmology and Center for Eye Research and Innovative Diagnostics, University of Oslo and Oslo University Hospital
• Team members: Eirik Albert Torheim, Inven2

BePREPAReD: Bedside PREvention of critical illness in Preterm infants using Artificial intelligence and eNose Devices?

• Project leader:??sbj?rn Schumacher Westvik, Department of Neonatal Intensive Care, Oslo University Hospital and Faculty of Medicine, University of Oslo
• Team members: Dr. Sissel Jennifer Moltu (PI, Oslo University Hospital), Prof. Oliver Tomic (Machine Learning & Chemometrics, NMBU), Dr. Alexander Rowe (Bioinformatics, Oslo University Hospital), Prof. Charlotte Tscherning (Neonatologist, University of Oslo)

Resolving bacterial infections?

• Project leader:?Professor Trond Vidar Hansen, Department of Pharmacy, University of Oslo
• Team members: Associate professor Osman Gani Dept. of Pharmacy), Post. Doctoral-Fellow Dr. Amalie F. Reinertsen (Dept. of Pharmacy), PhD-student Daniel H. Hasselstr?m (Dept. of Pharmacy) and Beate Rygg Johnsen (UiO Growth House).

Drug discovery for assisted amyloid beta peptide clearance?

• Project leader:?Tormod Fladby, Department of Neurology, Akershus University Hospital?(Ahus)
• Team members: Marianne Wettergren (Senior biotechnician, Ahus), Berglind Gisladottir (Senior biotechnician, Ahus), Bj?rn-Eivind Kirsebom (Biostatistician, University Hospital of Northern Norway), Peter Mikael Arnesen (Bioinformatician, Ahus) and Panpan You (Researcher, Ahus)?

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ProClass ¨C A patient-specific molecular classifier independent of heterogeneity in primary prostate cancer

• Project leader:?Bjarne Johannessen, Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital
• Team members: Rolf I. Skotheim, Karol Axcrona, Ragnhild A. Lothe, Ulrika Axcrona, Tor ?ge Myklebust, Susanne G. Kidd, Anne Cathrine Bakken, Lise R?dsten

Wearable Electrophysiology Mobility Solutions in Parkinson¡¯s Disease [WEBSPD]

• Project leader: Tarun Arora, Researcher, Department of Neurology, Oslo University Hospital
• Team members: Mathias Toft (UiO), Christian Tronstad (OUH), Kristian Bernhard Nilsen (OUH), Lasse Pihlstr?m?(OUH)

Small molecules targeting FoxP3+ Regulatory T cells for cancer immunotherapy

• Project leader:?Qian Wei, Postdoctoral researcher, Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital
• Team members: Professor Kjetil Task¨¦n (UiO/OUH), Professor Rafi Ahmad (INN University), Postdoc Nuria Garc¨ªa-D¨ªaz (OUH) and UiO Growth House

Blocking pancreatic cancer by small-molecule inhibitors

• Project leader:?Bj?rn Dalhus, Researcher, Department for Medical Biochemistry, Institute of Clinical Medicine, University of Oslo
• Team members: Professor Lars Eide, Department for Medical Biochemistry, UiO,?Pernille Blicher, UiO and Marte Eikenes, UiO

Advanced Technology for Identifying and Detecting RNA Modification-Based Cancer Markers

• Project leader:?Yanjiao Li,?Postdoctoral researcher, Oslo University Hospital
• Team members: Arne Klungland, Professor and Director CRESCO - Centre for Embryology and Healthy Development, Institute of Clinical Medicine, University of Oslo

Autologous cell-based therapy for coagulation factor deficiency

• Project leader:?Giacomo Roman, Department of Haematology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital
• Team members: Maria E. Chollet (UiO/OUS), Anindita Bhattacharya (UiO/OUS), Knut Lauritzen (UiO/OUS), Christian Qvigstad (UiO/OUS), Gareth Sullivan (OUS), Per Morten Sandset (UiO/OUS), Benedicte Stavik (OUS)

Blood-based test for solid cancer early detection

• Project leader: Carmen Herrera, Section for Biochemistry and Molecular Biology, Department of Biosciences, University of Oslo
• Team members:?P?l Falnes (UiO) and UiO Growth House

Ligament balancing in total knee arthroplasty - a systematic approach to Bellemans technique

• Project leader: Lars Engseth, Department of Orthopaedics - Ullev?l, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital
• Team members:?Stephan R?hrl (OUS/UiO), J?rgen Gr?nsund (UiS/Moreld Capnor)

EvoMab: germinal center guided affinity maturation of therapeutic antibodies

• Project leader: Johanne Jacobsen, Department of Immunology, Institute of Clinical Medicine, University of Oslo
• Team member: Valgerdur Bj?rnsdottir (UiO)

Mathematical biomarkers for personalized cancer medicine

• Project leader:?Alvaro K?hn-Luque,?Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo and Department of Medical Genetics, Oslo University Hospital
• Team members:? Arnoldo Frigessi (UiO/OUS), Aleix Prat (Hospital Clinic Barcelona), Fara Bras¨®-Maristany (Hospital Clinic Barcelona), Vessela Kristensen (OUS/UiO), Leonard Schmiester (OUS)

PharmaChip

• Project leader:Steven Ray Wilson, Section for Chemical Life Sciences - Biomolecules, Bio-inspired Materials and Bioanalytics, University of Oslo
• Team members: Fr?ydis Sved Skottvoll (SINTEF), Aleksandra Aizenshtadt (UiO), Stefan Krauss (UiO/OUS), Stig Pedersen-Bjergaard (UiO), Michal Mielnik (SINTEF)

Development of engineered NK-EVs for Targeted Therapy in Breast Cancer

• Project leader: Marit Inngjerdingen, Dept. of Pharmacology, Institute of Clinical Medicine, Faculty of Medicine, UiO
• Team members: Amanda Sudworth (UiO) and?J?rgen Wesche (OUS/UiO)?

Personalized Rapid Ex vivo Determination of Immunotherapeutic Cancer Treatment (PREDICT)

• Project leader: Audun Kvalvaag, Institute for Cancer Research, Oslo University Hospital
• Team members: Dr. Ieva Ailte (OUS) and Professor Harald Stenmark (OUS/UiO)

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